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Nitric Oxide Formula

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Price: $36.00
Item Number: 2840F
Manufacturer Part No: 2840F

Nitric Oxide (NO) plays a very important role in relationship to cardiovascular health. It also participates in virtually every cellular function in the body. Since NO is a vasodilator, its benefits are also noted for contributing to sexual health in males. Low levels are associated with health imbalances, so for optimal functioning, we should be sure to maintain sufficient levels in the bloodstream. Genetics can greatly influence NO metabolism, and since the importance of nitric oxide production and management in the human body can appear complicated, a clarified overview will help.

Increasing levels of NO must be done safely, because NO can form dangerous peroxynitrites (potent free radicals) in the absence of nutritional support (antioxidants). Peroxynitrite is a very damaging molecule that is produced when the body tries to fight infections. It damages the cells of bacteria, viruses and other foreign invaders however if this molecule is not broken down well, it can attack our own tissues through the production of free radicals. This may lead to chronic inflammation, imbalances, and cell membrane damage.

In addition to environmental and dietary imbalances contributing to low levels, genetic variants can also affect circulating NO levels. Genetic variants in the SOD (superoxide dismutase), CAT (catalase), GPx (glutathione peroxidase) and NOS (nitric oxide synthase) genes can have a profound effect on nitic oxide levels in the body. These enzymes may affect NO levels by using up nitric oxide to quench free radicals or by decreasing production of nitric oxide.

Nutritional interventions can be a tremendous help to balancing out these critical metabolites. By adding antioxidants to quench free radical production and adding in potent precursors to NO, we can optimize levels in the body and reduce risks of imbalances tha can lead to many health risks.

There are three types of NO in the body; neuronal, endothelial, and inducible. These three types of NO have very different roles in the body. The neuronal form (nNOS) is involved in cell to cell communication; the endothelial form (eNOS) is involved in arterial health, vascular tone and blood flow; and the inducible form (iNOS) is involved in immune system response.

Genetic variants in the nNOS, eNOS and iNOS genes can cause low levels to be produced. In the past, arginine was used to raise NO levels without tremendous success due to the fact that variants in one or more of these genes it can block the conversion of arginine to NO. Evidence suggests that the conversion of arginine to NO occurs in the arterial system but the arginine molecule can have difficulty passing into the circulation system from the digestive system. Citrulline, on the other hand, can pass through into the circulation much more easily. This makes converting citrulline to arginine in the system the best way to raise NO more successfully. This is especially true when the genetic variants are slowing that conversion down. NO production requires several cofactors, including tetrahydrobiopterin (BH4). This molecule is produced when the methylation cycle is functioning correctly. FAD (flavin adenine dinucleotide) is another important cofactor (a product of the Krebs cycle) as is FMN (flavin mononucleotide) a riboflavin derivative. Lastly, the heme molecule in red blood cells is also a cofactor. Nitric Oxide can be reduced to the superoxide molecule (another damaging free radical) in the case of a deficiency of arginine or BH4. This so called “uncoupling” has been known to occur in sugar, pressure and fat imbalances. Optimal levels of NO can lead to tremendous changes in cardiovascular profiles. It has been shown to help health imbalances by dilating blood vessels. In addition, it supports an anti-inflammatory environment by clearing up free radical damage. It also supports the immune system response by cleaning up chronic immune attacks that can lead to inflammation. It has even been shown to support the elimination of parasitic infections .